11th Brain Research Conference

4th RNA Metabolism in Neurological Disease

Satellite to the 2016 Meeting of SfN

November 10-11, 2016 | Paradise Point, San Diego, USA

Complex networks of RNA-protein interactions regulate post-transcriptional gene expression. RNA metabolism is particularly complex in neurons, involving extensive diversification of gene expression through splicing and redistribution of RNA subsets to the distant compartments where they ultimately function. In recent years, perturbation of RNA metabolism has emerged as a consistent underlying defect in certain neurological diseases, suggesting that aspects of RNA metabolism that are unique to the nervous system may also create unique vulnerabilities.

This two-day symposium organized by Paul Taylor and Fen-Biao Gao will bring together basic and clinical scientists to discuss the role of perturbed RNA metabolism in neurological diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), spinal muscular atrophy (SMA), and repeat expansion disorders.

Topics will include:

  • RNA binding proteins in the pathogenesis of neurological diseases
  • C9ORF72 repeat expansion in neurological disorders
  • RAN translation in repeat expansion diseases
  • RNA granules and axonal transport
  • Cellular and animal models of RNA defects
  • Emerging therapeutic approaches
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